950 research outputs found
A Tale of Two Animats: What does it take to have goals?
What does it take for a system, biological or not, to have goals? Here, this
question is approached in the context of in silico artificial evolution. By
examining the informational and causal properties of artificial organisms
('animats') controlled by small, adaptive neural networks (Markov Brains), this
essay discusses necessary requirements for intrinsic information, autonomy, and
meaning. The focus lies on comparing two types of Markov Brains that evolved in
the same simple environment: one with purely feedforward connections between
its elements, the other with an integrated set of elements that causally
constrain each other. While both types of brains 'process' information about
their environment and are equally fit, only the integrated one forms a causally
autonomous entity above a background of external influences. This suggests that
to assess whether goals are meaningful for a system itself, it is important to
understand what the system is, rather than what it does.Comment: This article is a contribution to the FQXi 2016-2017 essay contest
"Wandering Towards a Goal
China’s rising hydropower demand challenges water sector
Demand for hydropower is increasing, yet the water footprints (WFs) of reservoirs and hydropower, and their contributions to water scarcity, are poorly understood. Here, we calculate reservoir WFs (freshwater that evaporates from reservoirs) and hydropower WFs (the WF of hydroelectricity) in China based on data from 875 representative reservoirs (209 with power plants). In 2010, the reservoir WF totaled 27.9 × 109 m3 (Gm3), or 22% of China’s total water consumption. Ignoring the reservoir WF seriously underestimates human water appropriation. The reservoir WF associated with industrial, domestic and agricultural WFs caused water scarcity in 6 of the 10 major Chinese river basins from 2 to 12 months annually. The hydropower WF was 6.6 Gm3 yr−1 or 3.6 m3 of water to produce a GJ (109 J) of electricity. Hydropower is a water intensive energy carrier. As a response to global climate change, the Chinese government has promoted a further increase in hydropower energy by 70% by 2020 compared to 2012. This energy policy imposes pressure on available freshwater resources and increases water scarcity. The water-energy nexus requires strategic and coordinated implementations of hydropower development among geographical regions, as well as trade-off analysis between rising energy demand and water use sustainability
Characterization of a novel and spontaneous mouse model of inflammatory arthritis
Abstract Introduction Mouse models of rheumatoid arthritis (RA) have proven critical for identifying genetic and cellular mechanisms of the disease. Upon discovering mice in our breeding colony that had spontaneously developed inflamed joints reminiscent of RA, we established the novel IIJ (inherited inflamed joints) strain. The purpose of this study was to characterize the histopathological, clinical, genetic and immunological properties of the disease. Methods To begin the IIJ strain, an arthritic male mouse was crossed with SJL/J females. Inheritance of the phenotype was then tracked by intercrossing, backcrossing and outcrossing to other inbred strains. The histopathology of the joints and extraarticular organ systems was examined. Serum cytokines and immunoglobulins (Igs) were measured by ELISA and cytometric bead array. Transfer experiments tested whether disease could be mediated by serum alone. Finally, the cellular joint infiltrate and the composition of secondary lymphoid organs were examined by immunohistochemistry and flow cytometry. Results After nine generations of intercrossing, the total incidence of arthritis was 33% (304 of 932 mice), with females being affected more than males (38% vs. 28%; P < 0.001). Swelling, most notably in the large distal joints, typically became evident at an early age (mean age of 52 days). In addition to the joint pathology, which included bone and cartilage erosion, synovial hyperproliferation and a robust cellular infiltration of mostly Gr-1+ neutrophils, there was also evidence of systemic inflammation. IL-6 was elevated in the sera of recently arthritic mice, and extraarticular inflammation was observed histologically in multiple organs. Total serum Ig and IgG1 levels were significantly elevated in arthritic mice, and autoantibodies such as rheumatoid factor and Ig reactive to joint components (collagen type II and joint homogenate) were also detected. Nevertheless, serum failed to transfer disease. A high percentage of double-negative (CD4-CD8-) CD3+ TCRα/β+ T cells in the lymphoid organs of arthritic IIJ mice suggested significant disruption in the T-cell compartment. Conclusions Overall, these data identify the IIJ strain as a new murine model of inflammatory, possibly autoimmune, arthritis. The IIJ strain is similar, both histologically and serologically, to RA and other murine models of autoimmune arthritis. It may prove particularly useful for understanding the female bias in autoimmune diseases
Relations among neutrino observables in the light of a large theta_13 angle
The recent T2K and MINOS indications for a "large" theta_13 neutrino mixing
angle can be accommodated in principle by an infinite number of Yukawa flavour
structures in the seesaw model. Without considering any explicit flavour
symmetry, there is an instructive exercise one can do: to determine the
simplest flavour structures which can account for the data with a minimum
number of parameters, simply assuming these parameters to be uncorrelated. This
approach points towards a limited number of simple structures which show the
minimum complexity a neutrino mass model must generally involve to account for
the data. These basic structures essentially lead to only 4 relations between
the neutrino observables. We emphasize that 2 of these relations, |sin
theta_13|=(tan theta_23/cos delta)*(1-tan theta_12)/(1+tan theta_12) and |sin
theta_13| = sin theta_12 R^1/4, with R= Delta m^2_21/Delta m^2_32, have several
distinctive properties. First, they hold not only with a minimum number of
parameters, but also for complete classes of more general models. Second, any
value of theta_13 within the T2K and MINOS ranges can be obtained from these
relations by taking into account small perturbations. Third, they turn out to
be the pivot relations of models with approximate conservation of lepton
number, which allow the seesaw interactions to induce observable flavour
violating processes, such as mu -> e gamma and tau -> mu gamma. Finally, in
specific cases of this kind, these structures have the rather unique property
to allow a full reconstruction of the seesaw Lagrangian from low energy data.Comment: 13 pages, 3 figure
Nitrides as ammonia synthesis catalysts and as potential nitrogen transfer reagents
In this article, an overview of the application of selected metal nitrides as ammonia synthesis catalysts is presented. The potential development of some systems into nitrogen transfer reagents is also described
Wind from the black-hole accretion disk driving a molecular outflow in an active galaxy
Powerful winds driven by active galactic nuclei (AGN) are often invoked to
play a fundamental role in the evolution of both supermassive black holes
(SMBHs) and their host galaxies, quenching star formation and explaining the
tight SMBH-galaxy relations. Recent observations of large-scale molecular
outflows in ultra-luminous infrared galaxies (ULIRGs) have provided the
evidence to support these studies, as they directly trace the gas out of which
stars form. Theoretical models suggest an origin of these outflows as
energy-conserving flows driven by fast AGN accretion disk winds. Previous
claims of a connection between large-scale molecular outflows and AGN activity
in ULIRGs were incomplete because they were lacking the detection of the
putative inner wind. Conversely, studies of powerful AGN accretion disk winds
to date have focused only on X-ray observations of local Seyferts and a few
higher redshift quasars. Here we show the clear detection of a powerful AGN
accretion disk wind with a mildly relativistic velocity of 0.25c in the X-ray
spectrum of IRAS F11119+3257, a nearby (z = 0.189) optically classified type 1
ULIRG hosting a powerful molecular outflow. The AGN is responsible for ~80% of
the emission, with a quasar-like luminosity of L_AGN = 1.5x10^46 erg/s. The
energetics of these winds are consistent with the energy-conserving mechanism,
which is the basis of the quasar mode feedback in AGN lacking powerful radio
jets.Comment: Revised file including the letter, methods and supplementary
information. Published in the March 26th 2015 issue of Natur
On hypercharge flux and exotics in F-theory GUTs
We study SU(5) Grand Unified Theories within a local framework in F-theory
with multiple extra U(1) symmetries arising from a small monodromy group. The
use of hypercharge flux for doublet-triplet splitting implies massless exotics
in the spectrum that are protected from obtaining a mass by the U(1)
symmetries. We find that lifting the exotics by giving vacuum expectation
values to some GUT singlets spontaneously breaks all the U(1) symmetries which
implies that proton decay operators are induced. If we impose an additional
R-parity symmetry by hand we find all the exotics can be lifted while proton
decay operators are still forbidden. These models can retain the gauge coupling
unification accuracy of the MSSM at 1-loop. For models where the generations
are distributed across multiple curves we also present a motivation for the
quark-lepton mass splittings at the GUT scale based on a Froggatt-Nielsen
approach to flavour.Comment: 38 pages; v2: emphasised possibility of avoiding exotics in models
without a global E8 structure, added ref, journal versio
Spontaneous R-Parity Violation, Flavor Symmetry and Tribimaximal Mixing
We explore the possibility of spontaneous R parity violation in the context
of flavor symmetry. Our model contains singlet matter chiral superfields which are arranged as triplet of
and as well as few additional Higgs chiral superfields which are singlet
under MSSM gauge group and belong to triplet and singlet representation under
the flavor symmetry. R parity is broken spontaneously by the vacuum
expectation values of the different sneutrino fields and hence we have
neutrino-neutralino as well as neutrino-MSSM gauge singlet higgsino mixings in
our model, in addition to the standard model neutrino- gauge singlet neutrino,
gaugino-higgsino and higgsino-higgsino mixings. Because all of these mixings we
have an extended neutral fermion mass matrix. We explore the low energy
neutrino mass matrix for our model and point out that with some specific
constraints between the sneutrino vacuum expectation values as well as the MSSM
gauge singlet Higgs vacuum expectation values, the low energy neutrino mass
matrix will lead to a tribimaximal mixing matrix. We also analyze the potential
minimization for our model and show that one can realize a higher vacuum
expectation value of the singlet
sneutrino fields even when the other sneutrino vacuum expectation values are
extremely small or even zero.Comment: 18 page
Evolutionary History of the HAP2/GCS1 Gene and Sexual Reproduction in Metazoans
The HAP2/GCS1 gene first appeared in the common ancestor of plants, animals, and protists, and is required in the male gamete for fusion to the female gamete in the unicellular organisms Chlamydomonas and Plasmodium. We have identified a HAP2/GCS1 gene in the genome sequence of the sponge Amphimedon queenslandica. This finding provides a continuous evolutionary history of HAP2/GCS1 from unicellular organisms into the metazoan lineage. Divergent versions of the HAP2/GCS1 gene are also present in the genomes of some but not all arthropods. By examining the expression of the HAP2/GCS1 gene in the cnidarian Hydra, we have found the first evidence supporting the hypothesis that HAP2/GCS1 was used for male gamete fusion in the ancestor of extant metazoans and that it retains that function in modern cnidarians
Neutrino Mass and from a Mini-Seesaw
The recently proposed "mini-seesaw mechanism" combines naturally suppressed
Dirac and Majorana masses to achieve light Standard Model neutrinos via a
low-scale seesaw. A key feature of this approach is the presence of multiple
light (order GeV) sterile-neutrinos that mix with the Standard Model. In this
work we study the bounds on these light sterile-neutrinos from processes like
\mu ---> e + \gamma, invisible Z-decays, and neutrinoless double beta-decay. We
show that viable parameter space exists and that, interestingly, key
observables can lie just below current experimental sensitivities. In
particular, a motivated region of parameter space predicts a value of BR(\mu
---> e + \gamma) within the range to be probed by MEG.Comment: 1+26 pages, 7 figures. v2 JHEP version (typo's fixed, minor change to
presentation, results unchanged
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